2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-136450
    Triclabendazole sulfoxide
    		Inhibitor 98.34%
    Triclabendazole sulfoxide (TCBZ-SO) is an orally active ABCG2 inhibitor with antiparasitic activity. Triclabendazole sulfoxide inhibits ABCG2-mediated active efflux and ATPase activity. Triclabendazole sulfoxide increases the intracellular accumulation of Mitoxantrone (HY-13502). Triclabendazole sulfoxide reduces the apical-directed transepithelial transport of Nitrofurantoin and Danofloxacin, while increasing their basolateral-directed transepithelial transport. Triclabendazole sulfoxide elevates the plasma levels of sulfasalazine in wild-type mice. Triclabendazole sulfoxide decreases ABCG2-mediated secretion of Nitrofurantoin into milk in wild-type lactating mice. Triclabendazole sulfoxide can be used in the research of insecticidal agents and cancers such as breast cancer.
    Triclabendazole sulfoxide
  • HY-106005
    MMV390048
    		Inhibitor 98.85%
    MMV390048 is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 µM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. falciparum and human kinases apart from human PIP4K2C, thus alleviating potential kinase-mediated safety concerns. MMV390048 is an antimalarial agent.
    MMV390048
  • HY-B0887S
    Permethrin-d5
    		Inhibitor 99.21%
    Permethrin-d5 (NRDC-143-d5) is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.
    Permethrin-d<sub>5</sub>
  • HY-N0402S
    Artemether-d3
    		Inhibitor 99.97%
    Artemether-d3 is the deuterium labeled Artemether. Artemether is an antimalarial for the treatment of resistant strains of falciparum malaria.
    Artemether-d<sub>3</sub>
  • HY-B1282
    Sulfaquinoxaline
    		Inhibitor 99.46%
    Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections.
    Sulfaquinoxaline
  • HY-18684
    SIBA
    		Inhibitor 99.64%
    SIBA (5'-Isobutylthioadenosine) is a transmethylation inhibitor (SAH (HY-19528) analogue), with potent anti-proliferative activity. SIBA reversibly inhibits the production of HSV-1 by blocking methylation, specifically by blocking the 5' end-capping of viral mRNA. SIBA also inhibits the growth of tumour cells in vitro and metastatic spread in vivo. SIBA can be used in cancer, HSV-1 infection and anti-malaria studies.
    SIBA
  • HY-17596A
    Closantel sodium
    		Inhibitor 99.69%
    Closantel sodium is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel sodium is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel sodium inhibits the O. volvulus L3 to L4 molt of developing.
    Closantel sodium
  • HY-N8213
    Rapanone
    		Inhibitor 99.93%
    Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM.
    Rapanone
  • HY-107835
    Flumethrin
    		Inhibitor 99.29%
    Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide. Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer.
    Flumethrin
  • HY-B0147
    Pefloxacin
    		Inhibitor 99.37%
    Pefloxacin (Pefloxacinium) is a broad spectrum antibiotic. Pefloxacin blocks DNA replication by inhibiting DNA gyrase. Pefloxacin inhibits DNA relaxation catalyzed by topoisomerase I with an IC50 of 45 μg/mL. Pefloxacin exhibits antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Bacteroides fragilis with MIC90s of 0.12, 4, and 16 mg/L, respectively. Pefloxacin has anti-Plasmodium yoelii infection activity. Pefloxacin increase UVA-induced edema and immunesuppression. Pefloxacin can be used for infection studies.
    Pefloxacin
  • HY-N6009
    8-Deoxygartanin
    		Inhibitor 99.77%
    8-Deoxygartanin, a prenylated xanthones from G. mangostana, is a selective inhibitor of butyrylcholinesterase (BChE). 8-Deoxygartanin exhibits antiplasmodial activity with an IC50 of 11.8 μM for the W2 strain of Plasmodium falciparum. 8-Deoxygartanin inhibits NF-κB (p65) activation with an IC50 of 11.3 μM.
    8-Deoxygartanin
  • HY-135611
    Imidocarb
    		Inhibitor 99.42%
    Imidocarb is a potent antiprotozoal agent. Imidocarb is active against the parasite B. bovis with an IC50 of 87 μg/mL.
    Imidocarb
  • HY-W103183
    Ferron
    		99.43%
    Ferron (8-Hydroxy-7-iodo-5-quinolinesulfonic acid) has antiseptic and antifungal activity. Ferron can prevent skin and mucosa bacterial irritations and inflammations.
    Ferron
  • HY-W009993
    3,4-Methylenedioxycinnamic acid
    		Inhibitor 99.95%
    3,4-Methylenedioxycinnamic acid is an inhibitor of the 4-hydroxycinnamoyl-CoA ligase (4CL) with a Ki of 100 μM. 3,4-Methylenedioxycinnamic acid exhibits the Km value for the substrate ferulic acid of 4CL is 8.4 μM.3,4-Methylenedioxycinnamic acid increases the formation of soluble phenolics in particular of vanillic acid. 3,4-Methylenedioxycinnamic acid demonstrates larvicidal activity.
    3,4-Methylenedioxycinnamic acid
  • HY-B0318S2
    Metronidazole-d3
    		Inhibitor 99.97%
    Metronidazole-d3 is deuterium labeled Metronidazole.
    Metronidazole-d<sub>3</sub>
  • HY-N1198
    Strictosamide
    		Inhibitor 99.94%
    Strictosamide is a compound that can be isolated from Nauclea officinalis. Strictosamide has various activities such as anti-inflammatory, analgesic, anti-Plasmodium, antifungal, and promoting wound healing.
    Strictosamide
  • HY-126114
    Lupeol acetate
    		Inhibitor 98.0%
    Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility.
    Lupeol acetate
  • HY-P5285
    Lunasin
    		Inhibitor 98.22%
    Lunasin is a bioactive peptide with antioxidant, anti-inflammatory, anticancer and anti-aging properties. Lunasin can be isolated from soybean. Lunasin also has an epigenetic mechanism of action associated with histone acetylation. Lunasin can be internalized into cells and inhibit Oncosphere formation in cancer cells.
    Lunasin
  • HY-12642
    Diethylcarbamazine citrate
    		Inhibitor 98.01%
    Diethylcarbamazine citrate is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine citrate reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine citrate reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine citrate enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine citrate can be used for the researches of bronchial asthma, insulin resistance and infection.
    Diethylcarbamazine citrate
  • HY-17530
    Aldicarb sulfone
    		Inhibitor 99.46%
    Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase.
    Aldicarb sulfone
Parasite Isoform Comparison

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